The California Injury Attorney Blog has posted previously on boxed warnings issued by the United States Food and Drug Administration (FDA) for such drugs as Avandia. It is very important to learn about any warnings related to medications you are taking. These warnings are very important for both the public and healthcare professionals. This time we share important information about the drug Plavix.
Earlier this year, the FDA added a boxed warning to Plavix, which is used as an anti-blood clotting medication. Plavix has been the second-best selling drug in the world.
The drug is intended to reduce various risks, including heart attack, stroke and death in patients with heart disease. The drug is supposed to make platelets less likely to form blood clots.
In order for the drug to work, it has to be converted by the liver to its active form through the liver enzyme, CYP2C19. When this does not happen, the drug is not effective and researchers have been documenting the problem for some time.
In fact, the original warning label for this problem has been included since 2009. The additional warning added in March 2010, is intended to warn patients and healthcare professionals that for patients deemed “poor metabolizers,” the drug is not effective and those patients “may not receive the full benefits of the drug.”
The FDA’s boxed label warning includes information about the fact that the drug is not as effective in patients considered poor metabolizers. It also notes genetic testing that can be done to identify whether a patient has the requisite CYP2C19 function. And suggests alternative medications for those patients that fall into these categories.
Although patients have been advised not to stop taking Plavix unless they are told to do so by a healthcare provider, there are more proactive things that patients can do. Patients should ask about the possibility of taking a genetic test that will identify whether the drug will be effective.
Related Web Resources
For more information on the issues with Plavix, visit the Reuters update for the black boxed warning.
Hersh & Hersh
If you have questions or concerns about the use of Plavix, or if you have been taking the medication and have suffered a cardiac event while taking it, we are here to help. Contact the lawyers at San Francisco, California’s Hersh & Hersh for a free consultation and for more information. We represent clients across the nation.